I printed up and assembled a player handbook today just to see what it would look like:
I used the free OS X app CocoaBooklet to do the imposition for me. Printing was a bit tricky since I don't have a duplex printer at home but once I got that figured out the process was pretty easy.
I got the urge to tweak the prototype booklet a bit more and trimmed the top and bottom with a paper cutter. The edges didn't come out as clean as I had hoped so I'm going to try printing a faint trim line so that they can trimming can be done before folding.
Here are the pics: